comparisons - Difference between "Better than" and "More than"

Is it always possible to use "better than" and "more than" interchangeably?

Many users prefer the look and feel of A better than B.
Many users prefer the look and feel of A more than B.

Edit: The above examples are quoted from here:

Many users prefer the look and feel of GNOME 2 better than GNOME 3.
Thankfully, a fellow by the name of Ron Yorston already created an
extension pack that essentially transforms GNOME 3 into a logical
upgrade of GNOME 2, instead of the complete departure that GNOME Shell

is by default.

Answer

The difference is qualitative versus quantitative. When you refer to higher quality, you say better and when you mean a bigger quantity, you say more.
In a casual use, when detail really doesn't matter, and you only mean one over another in a general sense, you may use either word in most contexts.

In the given context, prefer takes over instead:
"Many users prefer the look and feel of A over B."