Should you always type a comma after "therefore","however" etc. in the beginning of a sentence? Also, when these (and similar) words are used in the middle of a sentence, should there be a comma or semi-colon before and after the word?
Therefore, he must be killed!
That man is revolting, however, some find him attractive.
Sorry for the lousy examples. I couldn't think of any better.
Answer
Not really. There are many cases for which a comma is unnecessary.
He is strong, and therefore a likely candidate.
However strong he is, he is not a likely candidate.
And so on.
As for subordinate clauses, where the words function as subordinating conjunctions, the comma isn't always necessary either.
He is strong, therefore he must be a likely candidate.
Still, I would use one with however in that case:
He is strong; however, I don't think he's a likely candidate.
Note the semicolon. A period would work there as well. This is because "however" doesn't really work as a subordinating conjunction. Therefore isn't usually classed as such either, but I believe it can function as one just fine.
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